First reported case of endometrial carcinoma in association with HIV infection

Endometrial adenocarcinoma is the most common gynecologic cancer in develop ed countries, although it has never before been documented in a female infe cted with human immunodeficiency virus (HIV). By contrast, cervical carcino ma is well described in association with HIV infection and in 1993 was adde d to the AIDS case definition. We present the unique case of a 38-year-old HIV-infected female with endometrial carcinoma, who became rapidly dissemin ated following her initial surgery. Although HIV is unlikely to have an eti ologic role in endometrial carcinoma, it is conceivable that immunosuppress ion contributed to an accelerated course of her malignancy.