Analysis of Bcl-2, Bax and Survivin genes in uterine cancer

Authors
Saitoh, Y Yaginuma, Y Ishikawa, M
Citation
Y. Saitoh et al., Analysis of Bcl-2, Bax and Survivin genes in uterine cancer, INT J ONCOL, 15(1), 1999, pp. 137-141
Citations number
19
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
INTERNATIONAL JOURNAL OF ONCOLOGY
ISSN journal
10196439 → ACNP
Volume
15
Issue
1
Year of publication
1999
Pages
137 - 141
Database
ISI
SICI code
1019-6439(199907)15:1<137:AOBBAS>2.0.ZU;2-Z
Abstract
To investigate the role of the apoptosis-related genes, Bcl-2, Bax and Surv ivin genes were analyzed. For the Bax gene, abnormality was detected in 1 o f 7 cervical and 1 of 6 endometrial cancer cell lines, 1 of 25 cervical can cer tissues and none of 17 endometrial cancer tissues using PCR-SSCP. In 4 cervical and 2 endometrial cancer cell lines, the ratio of Bcl-2 to Bar exp ression was higher than the control ratio using Western blotting. Survivin mRNA was detectable in all cell lines and all cancer tissues. The data sugg ested that these apoptosis-related genes may play important roles in the pa thway of carcinogenesis of human uterine cancer.