Solute-solvent interactions in micellar electrokinetic chromatography - Characterization of sodium dodecyl sulfate-Brij 35 micellar systems for quantitative structure-activity relationship modelling

The solvation parameter model has been applied to the characterization of m icellar electrokinetic chromatographic (MEKC) systems with mixtures of sodi um dodecyl sulfate and Brij 35 as surfactant. The variation in MEKC surfact ant composition results in changes in the coefficients of the correlation e quation, which in turns leads to information on solute-solvent and solute-m icelle interactions. Since the same solvation model can be used to describe many biological processes, particular MEKC surfactant compositions can be selected that model the solute-solvent interactions of some of these proces ses. Two different MEKC systems have been selected to model the solute-solv ent interactions of two processes of biological interest (octanol-water par tition and tadpole narcosis). (C) 1999 Elsevier Science B.V. All rights res erved.