Escherichia coli promotes macrophage apoptosis

Citation
Kg. Stravodimos et al., Escherichia coli promotes macrophage apoptosis, J ENDOUROL, 13(4), 1999, pp. 273-277
Citations number
26
Categorie Soggetti
Urology & Nephrology
Journal title
JOURNAL OF ENDOUROLOGY
ISSN journal
08927790 → ACNP
Volume
13
Issue
4
Year of publication
1999
Pages
273 - 277
Database
ISI
SICI code
0892-7790(199905)13:4<273:ECPMA>2.0.ZU;2-5
Abstract
Background: Escherichia coli is the bacterium most commonly isolated from t he urine of patients with urinary tract infection (UTI), Recurrent episodes of Un lead to renal interstitial scarring. In interstitial fibrosis and sc arring, infiltration of mononuclear cells has been reported to play a key r ole. Materials and Methods: We evaluated the effect of two strains of E. coli-th e pathogenic BH-5 and the plasmidless, nonfimbriated HB-101-on human monocy te and murine macrophage apoptosis, Results: E, coli BH-5 enhanced apoptosis in a time- and dose-dependent mann er. It also promoted necrosis in a time- and dose-dependent manner. Strain HB-101 promoted monocyte apoptosis in a dose-dependent manner. However, the magnitude of HB-101-induced monocyte apoptosis was lower than BH-5-induced macrophage apoptosis, Conclusion: The ability of E. coli to induce apoptosis may contribute to it s virulence and play a role in renal interstitial scarring.