An NcoI polymorphism in the human complement component 7 (C7) gene

Authors
Horiuchi, T Nishizaka, H Tsukamoto, H Harashima, S Sawabe, T Morita, C Niho, Y
Citation
T. Horiuchi et al., An NcoI polymorphism in the human complement component 7 (C7) gene, J HUM GENET, 44(4), 1999, pp. 270-271
Citations number
9
Categorie Soggetti
Molecular Biology & Genetics
Journal title
JOURNAL OF HUMAN GENETICS
ISSN journal
14345161 → ACNP
Volume
44
Issue
4
Year of publication
1999
Pages
270 - 271
Database
ISI
SICI code
1434-5161(1999)44:4<270:ANPITH>2.0.ZU;2-R
Abstract
A novel polymorphic site has been found in the 3' untranslated region (UTR) of the human complement component 7 (C7) gene. The polymorphic site at 14- bp downstream from the TAG stop codon was either C or A (Nco I-digested), w ith allele frequencies of 0.660 and 0.340. This NcoI polymorphism would be useful to perform a DNA marker haplotype study in patients with deficiencie s of the complement genes, such as C6, C7, C9, which are located closely on chromosome 5p13.