Synthesis and spectroscopic properties of copper(II) complexes derived from thiophene-2-carbaldehyde thiosemicarbazone. Structure and biological activity of [Cu(C6H6N3S2)(2)]
J. Garcia-tojal et al., Synthesis and spectroscopic properties of copper(II) complexes derived from thiophene-2-carbaldehyde thiosemicarbazone. Structure and biological activity of [Cu(C6H6N3S2)(2)], J INORG BIO, 75(1), 1999, pp. 45-54
The synthesis, structure and spectroscopic properties on complexes with the
formula [Cu(L-III)(2)] (1) and Cu(NO3)(2)(HLIII)(2) (2); where HLIII = thi
ophene-2-carbaldehyde thiosemicarbazone, have been developed. The molecular
structure of compound 1 consists of monomeric entities. The copper(II) ion
s exhibit distorted square-planar geometry with both bidentate thiosemicarb
azone ligands placed in a centrosymmetric way. Metal to ligand pi-backdonat
ion is proposed to explain several structural and spectroscopic features in
these complexes. The EPR spectra of compound 1 show an orthorhombic g tens
or indicating the presence of weak magnetic exchange interactions. The reac
tion of compound 1 with,glutathione causes the reduction of the metal ion a
nd the substitution of the thiosemicarbazone ligand by the thiol ligand. Th
is mechanism seems to be related to the cytotoxicity of this complex agains
t Friend Erithroleukemia cells (FLC) and melanome B16F10 cells. (C) 1999 El
sevier Science Inc. All rights reserved.