Iridoid glycosides of Leonurus persicus

Two new iridoid glucosides, 6-O-acetylajugol (1) and 7,8-epoxy-8-epi-logani c acid (2), together with five known iridoid glucosides, galiridoside (3), ajugoside (4), 10-deoxygeniposidic acid (5), 7-deoxy-8-epi-loganic acid (6) , and 8-O-acetylharpagide (7), have been isolated from the aerial parts of Leonurus persicus. Leucosceptoside A (8), eugenyl beta-rutinoside (9), and kaempferol 3-O-glucoside (10) were also isolated. The structures of 1 and 2 were elucidated by extensive 1D- and BD-NMR spectroscopy and molecular mod eling. The structure of 3 was confirmed by single-crystal X-ray diffraction . Antimicrobial activity of compounds (1-10) was also evaluated against a p anel of Gram-positive and Gram-negative bacteria and two strains of fungi.