Synthetic analogues of irlbacholine: A novel antifungal plant metabolite isolated from Irlbachia alata

Authors
Lu, Q Ubillas, RP Zhou, YH Dubenko, LG Dener, JM Litvak, J Phuan, PW Flores, M Ye, ZJ Gerber, RE Truong, T Bierer, DE
Citation
Q. Lu et al., Synthetic analogues of irlbacholine: A novel antifungal plant metabolite isolated from Irlbachia alata, J NAT PROD, 62(6), 1999, pp. 824-828
Citations number
18
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
01633864 → ACNP
Volume
62
Issue
6
Year of publication
1999
Pages
824 - 828
Database
ISI
SICI code
0163-3864(199906)62:6<824:SAOIAN>2.0.ZU;2-0
Abstract
Irlbacholine and a series of related analogues were synthesized and their a ntifungal activities against Candida albicans, Cryptococcus neoformans, and Aspergillus fumigatus were assessed. The natural bisphosphocholine, irlbac holine, was the most potent compound, its 22-carbon chain length appearing to be optimal.