Characterization of 6-epi-3-anhydroophiobolin B from Cochliobolus heterostrophus

Authors
Shen, XY Krasnoff, SB Lu, SW Dunbar, CD O'Neal, J Turgeon, BG Yoder, OC Gibson, DM Hamann, MT
Citation
Xy. Shen et al., Characterization of 6-epi-3-anhydroophiobolin B from Cochliobolus heterostrophus, J NAT PROD, 62(6), 1999, pp. 895-897
Citations number
9
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
01633864 → ACNP
Volume
62
Issue
6
Year of publication
1999
Pages
895 - 897
Database
ISI
SICI code
0163-3864(199906)62:6<895:CO6BFC>2.0.ZU;2-J
Abstract
The new sesterterpenoid 6-epi-3-anhydroophiobolin B (1) and six known ophio bolins were isolated from the extracts of the fungus Cochliobolus heterostr ophus race O. The structure of 6-epi-3-anhydroophiobolin B was deduced from analysis of spectral data and the structural characterization of dehydrati on and dimerization products. Ophiobolin A (2) showed potent activity in cy totoxicity assays and marginal activity in antimalarial assays.