Interference of linoleic acid fraction in some receptor binding assays

Authors
Ingkaninan, K Kunzel, JKVD IJzerman, AP Verpoorte, R
Citation
K. Ingkaninan et al., Interference of linoleic acid fraction in some receptor binding assays, J NAT PROD, 62(6), 1999, pp. 912-914
Citations number
15
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
01633864 → ACNP
Volume
62
Issue
6
Year of publication
1999
Pages
912 - 914
Database
ISI
SICI code
0163-3864(199906)62:6<912:IOLAFI>2.0.ZU;2-9
Abstract
An extract of a suspension culture of Tabernaemontana pandacaqui Poir. was fractionated by centrifugal partition chromatography. Aliquots were tested in an adenosine A(1) receptor binding assay. This led to the isolation and identification of linoleic acid, which proved to be a noncompetitive inhibi tor This "false positive" effect also extended to some other binding assays .