ANTIGEN RETRIEVAL IMMUNOHISTOCHEMISTRY - PRACTICE AND DEVELOPMENT

The antigen retrieval (AR) technique is a novel, simple, and reliable approach to routine immunohistochemistry (MC) developed in 1991. It ha s increasingly been used in pathology and analytical morphology, with a wide fruitful field opened for bath clinical and research projects. Hundreds of articles concerning AR-MC have been published in a variety of journals all over the world. As a recently developed technique, th e wide use of AR has raised numerous questions for further study. This review article focuses on several key points of the method and furthe r developments of the AR technique that are different from some review articles published recently.