Estradiol receptor and prognostic parameters of human breast cancer

Estradiol receptors are regarded to predict a likely success of hormonal th erapeutic efforts and the prognosis of breast cancer patients. But today it s prognostic importance is controversial, discussed as either reflecting in trinsic property of the tumor tissue or better therapeutic accessibility of receptor positive tumors. Moreover, the most important clinical prognostic ators - tumor size and axillary lymph node involvement do not seem to be re lated to the estradiol receptor status. In our investigation, the length of disease free interval is similar in est radiol receptor positive and negative patients and in all sites of distant metastases, but it is significantly reduced if more than 4 axillary lymph n odes are involved. Post recurrence survival is significantly longer in estradiol receptor posi tive than negative patients and also in patients treated by tamoxifen conta ining therapies. Its length is independent of the number of axillary lymph node metastases and the type of distant metastases, with a tendency to be l onger in estradiol receptor positive than negative patients. In addition, the overall survival is longer for estradiol receptor positive than negative patients and becomes reduced with more than 4 axillary lymph node metastases. Frequency of deaths in estradiol receptor positive patien ts is half that of negative subjects. Furthermore, the length of overall su rvival is independent on the type of distant metastases, with tendency to b e longer in estradiol receptor positive than negative patients. Longest ove rall survival could be observed for estradiol receptor positive patients wh o got therapy regimens containing tamoxifen. The weak prognostic advantages of estradiol receptor positive patients are interpreted by estradiol receptors as intrinsic parameters of breast cancer tissue characterizing more its biological behavior than therapeutic access ibility.