Lidocaine produces a shunt in rats thalamocortical neurons, unaffected by GABA(A) receptor blockade

Low concentrations of lidocaine reversibly decrease input resistance and sh unt action potentials in neurons of the ventral posterolateral thalamic nuc leus (VPL) in vitro. Using differential interference contrast infrared vide omicroscopy and whole-cell patch-clamp techniques in rat brain slices, we s tudied the effects of bicuculline methobromide to test whether the lidocain e-induced shunt in VPL neurons is mediated by GABAA receptors. Bicuculline (50 mu M) restored tonic firing rates to control values following reduction by lidocaine (10 mu M). However, bicuculline did not influence lidocaine's actions to decrease slope resistance over the voltage range from similar t o -90 mV to spike threshold. Likewise, bicuculline did not affect the shunt -induced reductio ns of spike-afterhyperpolarizations produced by lidocaine . The results of this study imply that the effects of low lidocaine concent rations in thalamocortical neurons are not mediated by GABAA receptors. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.