Authors
Citation
A. Behrooz et F. Ismail-beigi, Stimulation of glucose transport by hypoxia: Signals and mechanisms, NEWS PHYSL, 14, 1999, pp. 105-110
Citations number
15
Categorie Soggetti
Physiology
Journal title
NEWS IN PHYSIOLOGICAL SCIENCES
ISSN journal
08861714
→ ACNP
Volume
14
Year of publication
1999
Pages
105 - 110
Database
ISI
SICI code
0886-1714(199906)14:<105:SOGTBH>2.0.ZU;2-O
Abstract
Glucose transport is acutely stimulated by hypoxia through enhanced GLUT-I
and GLUT-4 glucose transporter function. GLUT-I expression is also stimulat
ed by hypoxia or azide. Moreover, hypoxia per se, acting through hypoxia-in
ducible factor I, enhances GLUT-1 transcription. GLUT-1 is the first gene w
hose transcription is dually stimulated in response to hypoxia and inhibiti
on of oxidative phosphorylation.