Sandalwood oil, the essential oil of Santalum album L., was tested for in v
itro antiviral activity against Herpes simplex viruses-1 and -2. It was fou
nd that the replication of these viruses was inhibited in the presence of t
he oil. This effect was dose-dependent and more pronounced against HSV-1. A
slight diminution of the effect was observed at higher multiplicity of inf
ections. The oil was not virucidal and showed no cytotoxicity at the concen
trations tested.