Effects of a small dose of triazolam on P300

Ten healthy men (mean age, 33.9 years) participated in two experimental ses sions cross-overed randomly in a double-blind manner: one with the placebo and another with 0.125 mg of triazolam (TRZ). Resting electroencephalograph y and event-related potential under oddball paradigm were recorded before t he drug administration, and 1, 2, 4, 6 and Sh after that. P300 waveforms we re analyzed by peak amplitudes and 30-ms bin data. Triazolam may cause cogn itive dysfunction without general sedation or apparent sleepiness, and this effect appeared 2 h, 3 h and 6 h. most prominently 6 h, after TRZ administ ration.