Effects of trazodone on polysomnography, blood concentration and core bodytemperature in healthy volunteers

Polysomnography. blood concentration and core body temperature recordings w ere performed on 12 healthy volunteers with administration of trazodone and placebo, Trazodone increased slow wave sleep (SWS), and decreased the aver age, the highest and lowest core body temperature significantly compared to placebo. The blood concentration of trazodone correlated positively with a mplitude (the difference between the highest and lowest temperature) and %S WS during the first period of a sleep phase divided into three periods, and negatively with the lowest temperature. The appearance time of the lowest temperature correlated negatively with %SWS.