Clinical characteristics of upper airway resistance syndrome

Polysomnographic findings and clinical symptoms were investigated in 14 cas es of upper airway resistance syndrome. The mean scores of the Epworth slee piness scale and self-rating depression scale in eight cases were 13.5 and 38.6, respectively. The mean sleep latency of the multiple sleep latency te st in four cases was 10.2 min. Seven cases were treated with continuous pos itive airway pressure (CPAP), and one with hormone replacement therapy. The most common symptom was daytime sleepiness. Five cases had hypertension. C PAP reduced increasing negative esophageal pressure (Pes) and frequency of EEG arousals, and improved hypertension in one case. Hormone replacement th erapy ameliorated increasing negative Pes and clinical symptoms.