Sporadic ulcerative-mutilating acropathy of the foot - Features and therapeutic indications

Ulcerative-mutilating acropathy occurs as an inherited (Thevenard's disease ) and a sporadic (Bureau-Barriere syndrome) variant. We report a retrospect ive study in nine patients with the sporadic variant. All nine had painless foot ulcers with trophic disorders and severe skeletal alterations. Electr odiagnostic testing showed polyneuropathy with sensory disorders in seven p atients. Motor conduction velocity was normal. Radiological changes were co nfined to the lower limbs. The clinical course and treatment of sporadic ul cerative-mutilating acropathy are presented.