Haematopathology of 'Sjogren-mice': Histopathological changes in spleens after semiallogeneic cell transfer

Haematopoietic transplantation chimeras may be readily produced in adult mi ce, using F-1-hybrids of selected inbred strains as recipients and mice fro m one of the parental strains as donors. We transplanted spleen cells from BALB/c donors into nonirradiateded F-1-hybrids of BALB/c and CBA/H-T6. Both female and male recipients developed a primacy Sjogren's syndrome-like exo crinopathy without signs of kidney disease. At long-term follow-up, 71/2 mo nths after cell transfer, lymph nodes were enlarged, and spleens were dimin ished and irregular in shape. In general, changes in haematopoietic organs were more prominent in males. The results verify that although hybrid mice of either sex develop glandular manifestations comparable with primary Sjog ren's syndrome, when the immune system is stimulated by semiallogeneic immu nocytes, the evoked reactions in haematopoietic tissues show gender differe nce.