SEROPREVALENCE, OF HUMAN IMMUNODEFICIENCY VIRUS-1, HEPATITIS-B VIRUS,AND HEPATITIS-C VIRUS IN PATIENTS HAVING MAJOR SURGERY

OBJECTIVE: To determine the proportion of major surgical procedures th at involve patients having serologic evidence of infection with human immunodeficiency virus-(HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV) in a single center in Westchester County, New York. METHO DS: Blood samples sent for transfusion screening or cross-match were t ested blindly for HIV antibody (anti-HIV), HBV core antibody, HBV surf ace antigen (HBsAg), and HCV antibody (anti-HCV). Demographic characte ristics and operation category were correlated with serologic results by univariate and regression analyses. RESULTS: Of 1,062 operations ev aluated, 71 (6.7%, 95% confidence interval [CI95], 5.2% to 8.4%) were per formed on patients with either anti-HIV, HBsAg, or anti-HCV. In 17 (1.6%, CI95, .93% to 2.5%) of these operations, the patient evidenced anti-HIV; in 15 (1.4%, CI95, .79% to 2.3%), HBsAg; and in 55 (5.2%, C I95, 3.9% to 6.7%), anti-HCV. Anti-HCV was detected significantly more often than anti-HIV (5.2% versus 1.6%, P<.001) or HBsAg (5.2% versus 1.4%, P<.001). Operations involving women aged 25 to 44 years had the highest proportion with serologic evidence of at least one of the thre e viruses (17.2%); of anti-HCV (15.3%); and of anti-HIV (6.7%). Logist ic regression analysis found that being in the 25- to 44-year age grou p was associated significantly with infection with any virus (P<.001) and with anti-HCV (P<.001). The strongest logistic predictors of anti- HIV seropositivity were having anti-HCV seropositivity (P<.001), being age 25 to 44 years (P<.001), and having a general surgery operation ( P=.002). CONCLUSION: The prevalences of serologic evidence of at least one of the three viruses (16.7%), of anti-HCV (14.5%), and of anti-HI V (5.6%) are high in patients aged 25 to 44 years undergoing major sur gery at a tertiary-care medical center located in Westchester County, New York. Anti-HCV is more prevalent than anti-HIV or HBsAg and is pre dictive of anti-HIV seropositivity. Testing for anti-HIV alone would h ave detected only 24% of patients infected with a bloodborne pathogen. These data strongly underscore the importance of universal precaution s (Infect Control Hosp Epidemiol 1995;16:627-632).