Since the report of a successful femoropopliteal in situ saphenous vein byp
ass in 1962, surgeons have attempted to make this bypass a less invasive op
eration and simplify the two principal technical components of the operatio
n: (1) rendering the saphenous vein valves incompetent and (2) occluding th
e venous side branches. To accomplish this bypass, however, a long incision
that is the length of the leg over the course of the saphenous vein is oft
en necessary, which can be fraught with hazard, especially in patients with
diabetes in whom wound complications can be devastating. An angioscopicall
y assisted technique that allows the surgeon to perform valvulotomy and occ
lude venous side branches from within the saphenous vein-a minimally invasi
ve in situ vein bypass-has been developed. This article discusses preclinic
al, fluoroscopic clinical, and angioscopic clinical studies of minimally in
vasive in situ bypass.