Novel synthesis and enzymatic resolution of (+/-)-2,3-epoxy propyl esters

Authors
Nair, RV Patil, PN Salunkhe, MM
Citation
Rv. Nair et al., Novel synthesis and enzymatic resolution of (+/-)-2,3-epoxy propyl esters, SYN COMMUN, 29(15), 1999, pp. 2559-2566
Citations number
14
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
SYNTHETIC COMMUNICATIONS
ISSN journal
00397911 → ACNP
Volume
29
Issue
15
Year of publication
1999
Pages
2559 - 2566
Database
ISI
SICI code
0039-7911(1999)29:15<2559:NSAERO>2.0.ZU;2-I
Abstract
A novel method of synthesizing glycidyl esters (+/-)-2,3-epoxy propyl ester s has been developed involving reaction of epichlorohydrin with sodium salt of carboxylic acids in the presence of 15-crown-5 as catalyst with excelle nt yields. Enzymatic resolution of these glycidyl esters by lipasePS-C has been achieved with remarkable substrate selectivity.