Phase-transition based transduction in a biosensor

Authors
Bardeau, JF Eberhardt, AS Nyquist, RM Parikh, AN Shreve, AP Swanson, BI
Citation
Jf. Bardeau et al., Phase-transition based transduction in a biosensor, SYNTH METAL, 102(1-3), 1999, pp. 1452-1453
Citations number
12
Categorie Soggetti
Apllied Physucs/Condensed Matter/Materiales Science
Journal title
SYNTHETIC METALS
ISSN journal
03796779 → ACNP
Volume
102
Issue
1-3
Year of publication
1999
Pages
1452 - 1453
Database
ISI
SICI code
0379-6779(199906)102:1-3<1452:PBTIAB>2.0.ZU;2-N
Abstract
Shifts in the main phase transition temperatures caused by a highly specifi c, protein-receptor interaction in a hybrid bilayer architecture are probed utilizing temperature programmed infrared vibrational spectroscopy. The sp ecific case of cholera toxin attachment to glycolipid receptors embedded in a phospholipid outer layer at a hydrophobized silicon surface is, investig ated. Potential applications of the approach as a signal amplification meth od in biosensor will be discussed.