Citation
R. Csuk et A. Kern, Synthesis of spacered cyclopropyl nucleoside analogues as potential antiviral agents, TETRAHEDRON, 55(28), 1999, pp. 8409-8422
Citations number
20
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON
ISSN journal
00404020
→ ACNP
Volume
55
Issue
28
Year of publication
1999
Pages
8409 - 8422
Database
ISI
SICI code
0040-4020(19990709)55:28<8409:SOSCNA>2.0.ZU;2-#
Abstract
Novel spacered cyclopropane nucleoside analogues possessing both a hydroxye
thyl group and an additional methylene spacer between the base and the ring
were synthesized starting from 3-buten-1-ol. After tetrahydropyranylation,
cyclopropanation, and reduction the target molecules were obtained by Mits
unobu reactions followed by two consecutive deprotection steps. (C) 1999 El
sevier Science Ltd. All rights reserved.