Citation
W. Lu et Cj. Sih, Chemoenzymatic synthesis of macrocyclic polyamines, TETRAHEDR L, 40(27), 1999, pp. 4965-4968
Citations number
19
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039
→ ACNP
Volume
40
Issue
27
Year of publication
1999
Pages
4965 - 4968
Database
ISI
SICI code
0040-4039(19990702)40:27<4965:CSOMP>2.0.ZU;2-S
Abstract
(+/-)-Azamacrolides were synthesized via lipase-catalyzed intramolecular cy
clization of (+/-)-hydroxy-azaesters. Further, the size of the macrocyclic
lactones formed could be altered by the substinuent on the nitrogen atom. T
his allows one to prepare a combinatorial library of azamacrolides from a s
mall number of hydroxy-azaesters using this biocatalytic approach. (C) 1999
Elsevier Science Ltd. All rights reserved.