An efficient synthesis of phenanthro-fused thiazoles by a non-phenolic oxidative coupling procedure of 4,5-diarylthiazoles

Authors
Moreno, I Tellitu, I SanMartin, R Badia, D Carrillo, L Dominguez, E
Citation
I. Moreno et al., An efficient synthesis of phenanthro-fused thiazoles by a non-phenolic oxidative coupling procedure of 4,5-diarylthiazoles, TETRAHEDR L, 40(27), 1999, pp. 5067-5070
Citations number
22
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
27
Year of publication
1999
Pages
5067 - 5070
Database
ISI
SICI code
0040-4039(19990702)40:27<5067:AESOPT>2.0.ZU;2-6
Abstract
A concise synthesis of the title compounds 6 is accomplished in high overal l yield in a two step process starting from bromoketone 4. A thiazole ring formation and a non-phenolic oxidative coupling reaction using PIFA are fea tures of me described synthesis. An exploration of the electronic requireme nts and the regioselectivity of the cyclization is also presented. (C) 1999 Elsevier Science Ltd. All rights reserved.