Synthesis of 3 '-deoxy-5 '-S-ethyl-5 '-thio-beta-D-erythro-pentofuranosylthymine as potential antitumor agent

Authors
Al-Masoudi, NA
Citation
Na. Al-masoudi, Synthesis of 3 '-deoxy-5 '-S-ethyl-5 '-thio-beta-D-erythro-pentofuranosylthymine as potential antitumor agent, TETRAHEDR L, 40(26), 1999, pp. 4795-4796
Citations number
12
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
40
Issue
26
Year of publication
1999
Pages
4795 - 4796
Database
ISI
SICI code
0040-4039(19990625)40:26<4795:SO3'''>2.0.ZU;2-3
Abstract
The title compound 6 was prepared from the key sugarintermediate 3-deoxy-1, 2-O-isopropylidene-alpha-D-erythro-pentofuranosylthymine (1) via five steps . Alternatively, 6 was synthesized from the nucleoside 3'-deoxy-beta-D-eryt hro-pentofuranosylthymine (7) in two steps. (C) 1999 Elsevier Science Ltd. All rights reserved.