Synthesis of (S)-1-(4-hydroxyphenyl)alcohols by eugenol dehydrogenase fromPseudomonas fluorescens E118

Authors
Wieser, M Furukawa, H Morita, H Yoshida, T Nagasawa, T
Citation
M. Wieser et al., Synthesis of (S)-1-(4-hydroxyphenyl)alcohols by eugenol dehydrogenase fromPseudomonas fluorescens E118, TETRAHEDR-A, 10(9), 1999, pp. 1627-1630
Citations number
9
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON-ASYMMETRY
ISSN journal
09574166 → ACNP
Volume
10
Issue
9
Year of publication
1999
Pages
1627 - 1630
Database
ISI
SICI code
0957-4166(19990507)10:9<1627:SO(BED>2.0.ZU;2-2
Abstract
(S)-1-(4-Hydroxyphenyl)ethanol and (S)-1-(4-hydroxyphenyl)propanol were syn thesized with enantiomeric excesses of 96.6% and 95.2%, respectively, from the corresponding 4-alkylphenols by eugenol dehydrogenase from Pseudomonas fluorescens E118. The enantioselectivity of the enzyme was shown to be pH-d ependent. (C) 1999 Elsevier Science Ltd. All rights reserved.