Asymmetric synthesis of enantiomerically pure spiro[((2S)-hydroxy)indane-1,4 '-piperidine]

Authors
Takemoto, T Nakajima, K Iio, Y Tamura, M Nishi, T
Citation
T. Takemoto et al., Asymmetric synthesis of enantiomerically pure spiro[((2S)-hydroxy)indane-1,4 '-piperidine], TETRAHEDR-A, 10(9), 1999, pp. 1787-1793
Citations number
14
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON-ASYMMETRY
ISSN journal
09574166 → ACNP
Volume
10
Issue
9
Year of publication
1999
Pages
1787 - 1793
Database
ISI
SICI code
0957-4166(19990507)10:9<1787:ASOEPS>2.0.ZU;2-A
Abstract
We report herein, efficient and practical synthetic methods for the prepara tion of enantiomerically pure spiro[((2S)-hydroxy)indane-1,4'-piperidine] ( S)-1, a key intermediate for the synthesis of a tachykinin receptor antagon ist, using catalytic asymmetric reduction or catalytic asymmetric epoxidati on as a key step. (C) 1999 Elsevier Science Ltd. All rights reserved.