Sry-negative XX true hermaphrodite in a Basset hound

A true hermaphrodite was diagnosed in a 7-mo-old Basset hound. The diagnosi s was based on the clinical signs, the histology of the gonads and the kary ogram. Additionally, the dog was tested for the Y-linked gene Sry, which wa s negative. The Basset hound presented here is compared to other XX sex rev ersed animals described in the literature. In man, XX sex reversal is a het erogenous condition. The pathogenesis in Sry-negative individuals is not un derstood. Thus Sry-negative animals could serve as an animal model of the h uman disease. (C) 1999 by Elsevier Science Inc.