Investigation of mechanisms of neuroprotective effect of Semax in acute period of ischemic stroke

Semax is the first domestic nootropic drug of an unexhausted type from the group of neuropeptides. in experimental studies it showed angioprotective, antihypoxic and neurotrophic activity in the doses 100-150 mu g/kg. A combi ned clinical-electrophysiologic study revealed its high efficiency in acute ischemic stroke. A clinical trial was performed of immunobiochemical mecha nisms of neuroprotective properties of Semax in acute period of ischemic st roke. A retrospective comparative clinicoimmunobiochemical analysis provise d objective data on the molecular level on activating influence of Semax on antiinflammatory postischemic reactions in the brain. Shitting neuromediat ory balance toward a prevalence of the antiinflammatory agents (interleukin -10, tumor necrosis factor-alpha) over the factors maintaining the inflamma tion (interleukin-8, C-reactive protein).