Clinical-immunobiochemical monitoring of the factors of local inflammationin the acute period of hemispheric ischemic stroke

The changes of cytokinis status and C-reactive protein were evaluated in ce rebrospinal fluid of 50 patients in the acute period of ischemic hemispheri c stroke with consideration of influence of the remote consequences of the ischemia, established experimentally, on the mechanisms of cerebral infarct ion development as well as on the progression of both atherogenesis and vas cular encephalopathy in the period after the stroke. Significance both of a surplus releasing of the proinflammatory cytokines and deficiency of the p rotective antiinflammatory and trophotropic factors in the development of a n inflammatory response was established. Immunobiochemical criteria were pr oposed for grading of process for stroke course prediction and for recovery of the altered neurologic functions. More favourable prognosis was anticip ated in the patients in which a the treatment started within of the "therap eutic window".