J. Joets et al., Characterization of FEN1 gene involved in sensitivity to Sterol Biosynthesis Inhibitors in Saccharomyces cerevisiae, ACT BOT GAL, 146(1), 1999, pp. 67-72
The study of yeast sensitivity to sterols biosynthesis inhibitors led us to
clone the FEN1 gene. Strains carrying defective allele of FEN1 gene are re
sistant to inhibitors of post-squalene biosynthesis steps. Overexpression o
f this gene causes hypersensitivity to these inhibotors. Other groups have
cloned FEN1 gene in different physiological contexts. We present here the c
hromosomal localisation of FEN1 at the YCR34W locus and results of investig
ations devoted to unterstand the function of this gene.