Citation
Rj. Mathew et al., Regional cerebral blood flow and depersonalization after tetrahydrocannabinol administration, ACT PSYC SC, 100(1), 1999, pp. 67-75
Citations number
74
Categorie Soggetti
Psychiatry,"Clinical Psycology & Psychiatry","Neurosciences & Behavoir
Journal title
ACTA PSYCHIATRICA SCANDINAVICA
ISSN journal
0001690X
→ ACNP
Volume
100
Issue
1
Year of publication
1999
Pages
67 - 75
Database
ISI
SICI code
0001-690X(199907)100:1<67:RCBFAD>2.0.ZU;2-A
Abstract
Objective: The aim of this study was to examine the relationship between de
personalization induced by tetrahydrocannabinol (THC), and regional brain a
ctivation.
Method: Cerebral blood flow (CBF) was measured by means of positron emissio
n tomography (PET) in 59 normal right-handed volunteers before and followin
g intravenous infusions of THC.
Results: After THC, CBF showed a global increase which was more marked in t
he right hemisphere, frontal lobes and anterior cingulate.
Conclusion: Regression analyses showed positive correlations between the ri
ght frontal and anterior cingulate and depersonalization.