COMPARISON OF THE SPECIFIC PRODUCTIVITY OF DIFFERENT CHIRAL STATIONARY PHASES USED FOR SIMULATED MOVING-BED CHROMATOGRAPHY

The use of preparative chromatography for the separation of enantiomer s is now a well established technique. With the technical setup of sim ulated moving bed-chromatography significant improvements can be achie ved regarding throughput and eluent consumption. To find the optimum s eparation system, the determination of some parameters with analytical chromatographic methods is sufficient. This article gives a procedure to optimize the separation conditions for a precursor of the novel Ca -sensitizing drug (EMD 53998.) on four different chiral stationary pha ses. This analytical procedure led to a maximum specific productivity for the desired enantiomer of 430 g enantiomer/d.kg chiral stationary phase.