Activation of protein kinase cascades in the heart by hypertrophic G protein-coupled receptor agonists

Cardiac myocyte hypertrophy involves changes in cell structure and alterati ons in protein expression regulated at both the transcriptional and transla tional levels. Hypertrophic G protein-coupled receptor (GPCR) agonists such as endothelin-1 (ET-1) and phenylephrine stimulate a number of protein kin ase cascades in the heart. Mitogen-activated protein kinase (MAPK) cascades stimulated include the extracellularly regulated kinase cascade, the stres s-activated protein kinase/c-Jun N-terminal kinase cascade, and the p38 MAP K cascade. All 3 pathways have been implicated in hypertrophy, but recent e x vivo evidence also suggests that there may be additional effects on cell survival. ET-1 and phenylephrine also stimulate the protein kinase B pathwa y, and this may be involved in the regulation of protein synthesis by these agonists, Thus, protein kinase-mediated signaling may be important in the regulation of the development of myocyte hypertrophy. (C)1999 by Excerpta M edica, Inc.