CHEMICAL AND BIOLOGICAL CHARACTERIZATION OF 2 FK506 ANALOGS PRODUCED BY TARGETED GENE DISRUPTION IN STREPTOMYCES SP MA6548

Authors
SHAFIEE A MOTAMEDI H DUMONT FJ ARISON BH MILLER RR
Citation
A. Shafiee et al., CHEMICAL AND BIOLOGICAL CHARACTERIZATION OF 2 FK506 ANALOGS PRODUCED BY TARGETED GENE DISRUPTION IN STREPTOMYCES SP MA6548, Journal of antibiotics, 50(5), 1997, pp. 418-423
Citations number
10
Categorie Soggetti
Pharmacology & Pharmacy",Immunology,"Biothechnology & Applied Migrobiology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
50
Issue
5
Year of publication
1997
Pages
418 - 423
Database
ISI
SICI code
0021-8820(1997)50:5<418:CABCO2>2.0.ZU;2-W
Abstract
Two genetically engineered mutant strains of Streptomyces sp. MA6548 p roduced two FK506 analogs, 9-deoxo-31-O-demethylFK506 and 31-O-demethy lFK506. The structures were determined by a combination of NMR and mas s spectrometry. These compounds exhibited immunosuppressive and antifu ngal activities, albeit reduced, compared to FK506. Both compounds con tain a free hydroxyl group at C-31 for the synthesis of novel FK506 de rivatives.