Topical pharyngeal anesthesia does not improve upper gastrointestinal endoscopy in conscious sedated patients

OBJECTIVE: We undertook this study to determine whether topical pharyngeal anesthesia with conscious sedation is superior to conscious sedation alone, with respect to procedure performance or tolerance in patients undergoing diagnostic upper gastrointestinal endoscopy. METHODS: Ninety-five patients undergoing diagnostic upper endoscopy with co nscious sedation were randomized to receive either topical pharyngeal anest hesia with 2% tetracaine/14% benzocaine spray or no pharyngeal anesthesia. Conscious sedation was achieved in all patients using intravenous midazolam and meperidine. Patients were asked to rate their pretest anxiety, comfort during endoscopy, recollection of the procedure, and willingness to underg o subsequent examinations using a 100-mm visual analog scale. Additionally, they were asked to estimate procedure duration and rate their tolerance fo r topical pharyngeal anesthesia. All examinations were performed by two end oscopists who were blinded to whether or not patients had received pharynge al anesthesia. Endoscopists were asked to determine whether they believed t hat patients had received topical pharyngeal anesthesia and to estimate eas e of esophageal intubation and procedure performance using a 100-mm visual analog scale. Procedure duration and doses of midazolam and meperidine were measured. RESULTS: The two groups did not differ with respect to age, gender, and pre vious endoscopic history. There were no significant differences between the two groups with respect to pretest anxiety, procedural comfort, and willin gness to undergo subsequent examinations. Patients receiving topical pharyn geal anesthesia rated it as moderately unpleasant. Endoscopists were able t o discriminate patients who received pharyngeal anesthesia from those who d id not with a sensitivity of 0.73 and a specificity of 0.59. There were no significant differences between the two groups with respect to ease of intu bation, procedure performance, procedure duration, and dosing of midazolam or meperidine. CONCLUSIONS: In patients undergoing diagnostic upper endoscopy using intrav enous midazolam and meperidine, the use of topical pharyngeal anesthesia do es not improve patient tolerance or procedure performance. Elimination of t his agent in the performance of diagnostic upper endoscopy will save time a nd money without adversely affecting patient care or outcomes. (Am J Gastro enterol 1999;94:1853-1856. (C) 1999 by Am. Coll. of Gastroenterology).