Clostridium difficile-associated diarrhea after short term vaginal administration of clindamycin

A 32-yr-old woman developed frequent watery diarrhea with occult blood afte r 3 days treatment with clindamycin vaginal cream. Clostridium difficile to xin was demonstrated in stool samples and was considered the cause of an an tibiotic-associated diarrhea. No other antibiotic was used at least 3 month s before the start of diarrhea. To our knowledge, antibiotic-associated dia rrhea after vaginal application has previously been reported only once. (Am J Gastroenterol 1999;94:1969-1970. (C) 1999 by Am. Coll. of Gastroenterolo gy).