Erythropoietin and iron use in peritoneal dialysis patients: Report from the 1997 HCFA end-stage renal disease Core Indicators Project

The HCFA ESRD Core Indicators Project is designed to assess several key ind icators of care in peritoneal dialysis patients, including anemia managemen t, information on hematocrit levels, epoetin alfa dosing, estimates of iron stores, and iron therapy as obtained in a national sample of 1,219 periton eal dialysis patients are described. The average hematocrit was 32.8% +/- 3 .8%, and severe anemia (hematocrit < 25%) occurred in 1.4% of PD patients. The mean weekly epoetin alfa dose was 134.6 U/kg, In general, there was an inverse relationship between hematocrit and epoetin alfa doses. Most (83%) of PD patients received iron therapy, with only 8% of patients receiving in travenous iron. The mean serum ferritin was 303 ng/mL, with 64% of patients having a ferritin greater than 100 ng/mL. The mean transferrin saturation was 28%, with 60% of patients having a value of less than 20%. There was an inverse relationship between serum ferritin levels and hematocrit but no r elationship between hematocrit and transferrin, It is concluded that there could be improvement in the epoetin alfa and iran management in many patien ts. (C) 1999 by the National Kidney Foundation, Inc.