Syntheses of optically active 2-amino-4-oxobutyric acid and N,O-protected derivatives

Strategies for the synthesis of optically active aspartaldehyde derivatives are reviewed. Most of them are using the chiral pool: allylglycine or natu rally occurring homoserine, aspartic acid or methionine and side chain modi fications. This will be developed in the first part. Some other original ro utes are also displayed in the second part. Different aspects of each strat egy are discussed: the nature and number of steps, the problem of protectin g groups. the price and availability of starting materials. Some synthetic applications of such interesting chiral synthons are shown in the last part .