Modern applications of analytical ultracentrifugation

Analytical ultracentrifugation is a classical method of biochemistry and mo lecular biology. Because it is a primary technique, sedimentation can provi de first-principle hydrodynamic and first-principle thermodynamic informati on for nearly any molecule, in a wide range of solvents and over a wide ran ge of solute concentrations. For many questions, it is the technique of cho ice. This review stresses what information is available from analytical ult racentrifugation and how that information is being extracted and used in co ntemporary applications.