Application of the ADEPT strategy to the MDR resistance in cancer chemotherapy

Authors
Desbene, S Van, HDT Michel, S Tillequin, F Koch, M Schmidt, F Florent, JC Monneret, C Straub, R Czech, J Gerken, M Bosslet, K
Citation
S. Desbene et al., Application of the ADEPT strategy to the MDR resistance in cancer chemotherapy, ANTI-CAN DR, 14(2), 1999, pp. 93-106
Citations number
48
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
ANTI-CANCER DRUG DESIGN
ISSN journal
02669536 → ACNP
Volume
14
Issue
2
Year of publication
1999
Pages
93 - 106
Database
ISI
SICI code
0266-9536(199904)14:2<93:AOTAST>2.0.ZU;2-5
Abstract
New prodrugs consisting of a beta-D-glucuronic acid linked to a MDR reversa l agent (verapamil, quinine or dipyridamole) through a self-immolative spac er were synthesized. Four of them were selected for their reduced cytoxicit y and beta-glucuronidase enzymatic efficient hydrolysis. Combined use of th ese prodrugs with a beta-D-glucuronyl-spacer-doxorubicin (HMR1826) accordin g to an ADEPT strategy restored in vitro the sensibility of a MDR resistant strain.