CLINICAL DETERMINANTS OF LONG-TERM SURVIVAL IN PATIENTS WITH GLIOBLASTOMA-MULTIFORME

Repeated reports of more than ten years postoperative survival in pati ents with glioblastoma multiforme (GM) have appeared In the literature over the last decades. Authors have tried to identify the clinical, t herapeutic and histological features determining long-term survival. W e present two patients in whom, after radical removal of the tumor fol lowed by conventional radiation, there has been no recurrence for at l east ten years. The young age of the patients and the radical surgical approach were in accordance with previous reports of long-term surviv al. Nevertheless, one tumor originated from the thalamus, a location c onsidered to be of unfavorable prognosis. We therefore further discuss the value of clinical signs as determinants in the prognosis of GM.