In vitro susceptibilities of Chlamydia pneumoniae isolates from German patients and synergistic activity of antibiotic combinations

The susceptibilities of six Chlamydia pneumoniae type strains and of six Ge rman patient isolates to erythromycin, azithromycin, roxithromycin, clarith romycin, doxycycline, ofloxacin, and rifampin were investigated. MICs and m inimal chlamydicidal concentrations were all within the ranges reported pre viously. Combinations of azithromycin with either ofloxacin, doxycycline, o r rifampin, as well as combinations of three antibiotics (rifampin, azithro mycin, and ofloxacin or doxycycline), showed synergistic activity against C . pneumoniae.