Improvement of in vitro and in vivo antileishmanial activities of 2',6 '-dihydroxy-4 '-methoxychalcone by entrapment in poly(D,L-lactide) nanoparticles

Authors
Torres-Santos, EC Rodrigues, JM Moreira, DL Kaplan, MAC Rossi-Bergmann, B
Citation
Ec. Torres-santos et al., Improvement of in vitro and in vivo antileishmanial activities of 2',6 '-dihydroxy-4 '-methoxychalcone by entrapment in poly(D,L-lactide) nanoparticles, ANTIM AG CH, 43(7), 1999, pp. 1776-1778
Citations number
23
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
43
Issue
7
Year of publication
1999
Pages
1776 - 1778
Database
ISI
SICI code
0066-4804(199907)43:7<1776:IOIVAI>2.0.ZU;2-F
Abstract
The inhibition of intracellular Leishmania amazonensis growth by 2',6'-dihy droxy 4'-methoxychalcone (DMC) isolated from Piper adruncum was further enh anced after encapsulation of DMC in polymeric nanoparticles. Encapsulated D MC also showed increased antileishmanial activity in infected BALB/c mice, as evidenced by significantly smaller lesions and fewer parasites in the le sions.