Sensitivity of the systemic lupus erythematosus disease activity index, British Isles lupus assessment group index, and systemic lupus activity measure in the evaluation of clinical change in childhood-onset systemic lupus erythematosus
Hi. Brunner et al., Sensitivity of the systemic lupus erythematosus disease activity index, British Isles lupus assessment group index, and systemic lupus activity measure in the evaluation of clinical change in childhood-onset systemic lupus erythematosus, ARTH RHEUM, 42(7), 1999, pp. 1354-1360
Objective. To investigate whether 3 disease activity indices commonly used
to evaluate systemic lupus erythematosus (SLE) in adults are sensitive to c
linical change in children, and thus suitable for the use in the management
of childhood-onset SLE.
Methods. Thirty-five SLE patients who were newly diagnosed between 1993 and
1997, had an age at onset of 6-16 years (26 female and 9 male), and were c
urrently being followed up at The Hospital for Sick Children (followup of 9
months to 4 years) were reviewed. The SLEDAI (Systemic Lupus Erythematosus
Disease Activity Index), BILAG (British Isles Lupus Assessment Group index
), and SLAM (Systemic Lupus Activity measure) were applied at up to 4 occas
ions during the disease course: at the time of diagnosis, 6 months postdiag
nosis, at the time of a flare (a deterioration in clinical presentation or
laboratory results requiring initiation or increase of either corticosteroi
ds or "second-line" drugs), and 6 months postflare. The sensitivity of the
3 measures to change, as gauged by the effect size (ES), effect size index
(ESI), standard response mean (SRM), responsiveness statistic (RS), and rel
ative efficiency index (REI), were compared.
Results, All 3 tools were very sensitive to change in disease activity (ES
>0.8, ESI >2.3, SRM >0.6, RS >0.86, REI >0.72), but were ranked differently
depending on the statistic used for comparison.
Conclusion. All 3 measures of disease activity are highly sensitive to clin
ical change in children; none showed an overall superiority. The SLEDAI, BI
LAG, and SLAM can ail be used to study response to treatment in children wi
th SLE.