D. Geffken et al., FACILE ROUTE TO 1-ALKOXY-3-PYRROLIN-2-ONES BY CYCLIC SULPHINYLATION OF N-ALKOXY-2-VINYLGLYCOLAMIDES, Heterocyclic communications, 3(2), 1997, pp. 127-133
The cyclic sulphinylation of 2-arylated N-alkoxy-2-vinylglycolamides 1
a-g leads to 3-arylated 1-alkoxy-3-pyrrolin-2-ones 2a-g via the short-
lived 1,2,3-oxathiazolidin-4-one 2-oxides 4 in good yields. The synthe
sis of the 3-methylated 1-benzyloxy-e-pyrrolin-2-one 2h could be accom
plished by thermolytic extrusion of sulfur dioxide from 4h.