SELENIUM-MEDIATED SYNTHESIS OF TETRAHYDROISOQUINOLINE RING-SYSTEMS - APPLICATION TO THE PREPARATION OF 6-DEOXY-2,3-DI-O-BENZYL LYCORICIDINE

Authors
IBNAHMED S CHRETIEN F CHAPLEUR Y HAJJAJ N
Citation
S. Ibnahmed et al., SELENIUM-MEDIATED SYNTHESIS OF TETRAHYDROISOQUINOLINE RING-SYSTEMS - APPLICATION TO THE PREPARATION OF 6-DEOXY-2,3-DI-O-BENZYL LYCORICIDINE, Heterocyclic communications, 3(2), 1997, pp. 135-138
Citations number
25
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Heterocyclic communications → ACNP
ISSN journal
07930283
Volume
3
Issue
2
Year of publication
1997
Pages
135 - 138
Database
ISI
SICI code
0793-0283(1997)3:2<135:SSOTR->2.0.ZU;2-R
Abstract
A strategy for the synthesis of the tetrahydroisoquinoline skeleton an d its application to the synthesis of a protected derivative of 6-deox y-lycoricidine are described. The key step of this sequence is the sel enium mediated B ring closure and subsequent selenoxide elimination to restore the C ring double bond.